MaxWell Publications
Peer-reviewed science and conference abstracts documenting our progress toward a non-destructive alternative to catheter ablation.
Heart Rhythm Society (HRS) 2026
Presented at the HRS in Chicago, Illinois, April 2026
Atrial fibrillation affects more than 37 million people worldwide and remains a leading cause of stroke, heart failure, and cardiovascular morbidity. While rhythm control has demonstrated superiority over rate control, achieving acute AF termination without high-energy shock remains an unmet clinical need.
Three abstracts were accepted for poster presentation at the Heart Rhythm Society (HRS) 2026 Annual Scientific Sessions in Chicago, IL, reporting on closed-loop adaptive pacing, SRT, and first-in-human results with left atrial multisite pacing.
Presented: 2026
Closed-loop Adaptive Pacing Outperforms Programmed Sequences for AF Termination
Termination of Atrial Fibrillation via Spatial Resynchronization Therapy (SRT)
Presented: 2026
Presented: 2026
Left Atrial Multisite Pacing (LAMSP) Achieves Global Control, Cycle Length Prolongation and AF Termination in Atrial Fibrillation: First-in-Human Results
European Heart Rhythm Association (EHRA) 2026
Presented at the EHRA annual congress in Paris, France, April 12th- 14th, 2026
Our team presented two posters at the European Heart Rhythm Association (EHRA) annual congress in Paris, France, highlighting our progress in developing a next-generation alternative to catheter ablation for atrial fibrillation.
Presented: 2026
Left atrial multi-site pacing achieves up to 10x greater AF cycle length prolongation vs. catheter ablation
Presented: 2026
Real-Time Global Control Index for adaptive Atrial Resynchronization: A Quantitative Mechanism for Novel AF Therapy
Heart Rhythm Society (HRS) 2022
Presented at HRS in San Francisco, CA, 2022
An interactive, physiologically realistic (PR), and accurate computer simulation allows multiple scenarios to be tested in a “live” environment and has become a key step in the rapid development and testing of treatment strategies for atrial fibrillation (AF). We developed a physiologically realistic computer model of AF that lets researchers define regions of anisotropic conduction and test treatment strategies in a live simulation.
Published: 2022
Physiologic, Realistic, Computer Modeling of Atrial Fibrillation to Facilitate the Development and Testing of Treatment Strategies
Scientific Reports (Nature Portfolio), 2022
About 30% of patients with impaired cardiac function have ventricular desynchrony and seek cardiac resynchronization therapy (CRT). In this study, we demonstrate synchronized biventricular (BiV) pacing in a leadless fashion by implementing miniaturized and wirelessly powered pacemakers.
Published: 2020
Synchronized Biventricular Heart Pacing in a Closed-Chest Porcine Model Based on Wirelessly Powered Leadless Pacemakers
Heart Rhythm Society (HRS) 2019
Presented at HRS in San Francisco, CA, 2019
Standard defibrillation relies on a large, painful shock, and patients with implanted cardioverters report significant pain and even post-traumatic stress from therapy. This preclinical study tested whether AF could be terminated by spreading low pacing power across multiple sites. In an acute porcine model, five pacing electrodes were placed on the left and right atria. Low-energy multisite pacing successfully terminated induced AF, supporting the goal of painless defibrillation. The authors note that further in vivo studies are needed.
Published: 2019